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Li, H., Guan, Y., Liang, B., Ding, P., Hou, X., Wei, W., & Ma, Y

The need to maintain a homeostatic relationship with the microbiota has been a driving factor force in the evolution of the human immune system and to keep the gut microbiota for its essential role in host metabolism and functions ( This alliance was reached by a fine-tuned contact modulation between gut bacteria and intestinal epithelial cells and by limiting the possible entrance of bacteria trough the mucosal layer

doi: 10.1371/journal.pone.0034693 194 MamaisAKlussJHBonet-PonceLLandeckNLangstonRGSmithNet al

Furthermore, inducing ferroptosis by inhibiting the cellular antioxidant system presents a potential therapeutic strategy for OS, as various anticancer agents exert their effects by targeting antioxidant system-related proteins such as GPX4 ( 3 Ferroptosis in bone microenvironment The bone microenvironment encompasses the local setting where bone tissue resides, comprising key cellular components such as osteoblasts, osteoclasts, and osteocytes within the tissue, along with adipocytes, vascular networks, immune cells, and an abundance of bone marrow and extracellular matrix (81)

doi: 10.1080/21655979.2021.2010369 65 LiSLiYWuZWuZFangH

By supporting GPx4 activity, L-Glutathione supplementation may help protect the mitochondria from structural collapse, supporting efficient ATP production