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[DOI] [PubMed] [Google Scholar] 2.Lee SM, Oh J, Chun MR, Lee SY (2019) Methylmalonic acid and homocysteine as indicators of vitamin B12 deficiency in patients with gastric cancer after gastrectomy

Clinical evidence: The SURMOUNT-1 trial, published in the New England Journal of Medicine , showed that participants on the highest dose of tirzepatide (15 mg) lost an average of 22.5 percent of their body weight over 72 weeks the most weight loss ever demonstrated by a pharmaceutical agent in a clinical trial (Jastreboff et al., 2022)

These may include: Persistent muscle soreness Joint stiffness or limited movement Tendon discomfort during activity Slow recovery after workouts or injuries Reduced skin elasticity or firmness These symptoms may appear gradually and often affect physically active adults