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Description

Oncogenic RIT1 mutations not only activate canonical RAS/MAPK and PI3K/AKT pathways but also modulate nuclear factor, erythroid 2 like 2 (NRF2) target expression, markedly increasing cellular susceptibility to ferroptosis inducers (33)

In vitro , we validated this increased gene expression via RT-qPCR and observed that BDG increases the global intracellular concentration of glutathione as well as the level of the oxidized glutathione (GSSG) form