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Clinical notes support a primary functional origin rather than a temporary or situational issue

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Ohanian M, Kantarjian HM, Shoukier M, Dellasala S, Musaelyan A, Nogueras Gonzalez GM, Jabbour E, Abruzzo L, Verstovsek S, Borthakur G , Ravandi F, Garcia-Manero G, Tamamyan G, Champlin R, Pierce S, Ferrajoli A, Kadia T, Cortes JE

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Complementary natural product-derived strategies include barley leaf supplementation (enriching Bifidobacterium to produce inosine, which activates PPAR signaling and attenuates colitis-associated tumorigenesis) (271) and icariin (a flavonoid from Epimedium ), which not only induces tumor ferroptosis via mitochondrial dysfunction but also synergizes with PD-1 inhibitors by reshaping the gut microbiota to reduce pro-inflammatory Escherichia coli and increase SCFA-producing Ruminococcus (272)

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