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reported that the LC-NA pathway maintains neural homeostasis by regulating microglial and astrocyte activation while controlling the release of inflammatory mediators (88)

As a result, NRF2 is freed from Keap1, with which it forms a complex, and is translocated into the nucleus where it binds to antioxidant responsive elements (AREs) in the promoters of target genes (Fig

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The table below summarizes some of the available treatment options that have shown potential in experimental models and their clinical status (Table 1)

Despite their benefits, antioxidants can have side effects

In brief, the Caco-2 cells were cultured in Dulbeccos modified Eagles medium (DMEM) supplemented with 10% fetal bovine serum (FBS) at 37C with 5% CO 2