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When these unstable molecules accumulate faster than the body's defenses can neutralize them, oxidative stress occurs, which may contribute to cellular damage over time

By molecular simulation, we have previously shown that YMU1 acts on the catalytic pocket of TMPK, which causes the expulsion of the lid domain to give an open conformation that inhibits the catalytic process 19

Moriguchi et al., 2019), a major strength of the multimodal neuroimaging approach of TIGER is that it allows us to integrate information from multiple neuroimaging modalities (e.g., fMRI, diffusion MRI) to enable us to reconcile these potential discrepancies in the literature and gain a more precise understanding of glutamatergic abnormalities underlying MDD (Salvadore and Zarate, 2010

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(1975) Erythrocyte 2,3-diphosphoglycerate as related to diabetes and obesity

Another strategy to extend levodopa efficacy involves inhibiting catechol-O-methyltransferase, an enzyme responsible for both peripheral levodopa degradation and central dopamine breakdown