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FDA explains that a bulk drug substance used through the 503A pathway generally must meet one of the following conditions: Comply with an applicable United States Pharmacopeia or National Formulary monograph Be a component of a drug product with federal marketing authorization when no applicable monograph exists Appear on the 503A Bulks List when the first two pathways do not apply Additional requirements also apply, including documentation and sourcing requirements for the bulk drug substance

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GSH depletion also activates the nuclear factor erythroid 2-related factor 2 ( NRF2 ), a transcription factor that induces expression of several cellular antioxidant defense genes 16,17