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In fact, MOTS-c levels naturally rise during exercise, and giving MOTS-c to mice has been shown to enhance their physical performance (they can run longer on a treadmill)

REDEFINE and SURMOUNT enrolled different cohorts (including with-diabetes vs without-diabetes arms), and diabetes status alone shifts expected weight loss

That works until it doesn't and the confounding variable of behavioral change makes clean research data nearly impossible

Comparing them across categories like peptides for weight loss and pharmaceutical GLP-1 agonists helps frame the decision more clearly

doi:10.1136/bmj.324.7352.1512 Song C, He J, Chen J, et al

Both claim to help people lose body fat, but they could not be more different in how they work, what the science says, and what you should realistically expect