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Description

It is thought that over time, the disease shifts from an early hypermetabolic state to a hypometabolic state with decreased metabolites (251) and reduced energy production (185)

Matsuyama, R

Confocal microscopic analysis showed that the fusion protein IbRAP2.4-GFP was specifically localized to the nuclei, suggesting that IbRAP.4 is a nuclear-localized protein (Figure 1B)

Because RP is a chronic condition, the development of a minimally invasive therapeutic that reduces frequency of application with local administration is appealing to reduce risk of non-adherence