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During the transport process from the intestinal lumen to portal blood, the proportion of butyrate decreased significantly from 21% to 8%, with its concentration further declining sequentially from the portal vein (29 mol/L) to the hepatic vein (12 mol/L) and finally to the peripheral vein (4 mol/L), demonstrating that butyrate uptake was most substantial in the colon, followed by the liver, and then further absorbed in peripheral tissues [1]

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It enables compensatory exchange of mtDNA-encoded products and metabolites between organelles, counteracting functional deficits arising from ROS-induced mtDNA mutations