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During the harvest, drying, and storage of Cannabis sativa or when heat via smoking, the carboxylated phytocannabinoids are decarboxylated, and therefore, converted into the corresponding chemically neutral version [40,41]

In summary, the currently identified cuproptosis-related genes may modulate cuproptosis through the following core mechanisms in WD: i) Regulation of lipoic acid metabolism: Genes such as FDX1, LIPT1 and LIAS can influence the TCA cycle and Fe-S cluster stability by participating in lipoic acid metabolism