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Therefore, TJs restrict the free transportation of polar solutes such as ions and solutes through paracellular diffusion channels by imparting the high transendothelial electrical resistance (TEER) of the BBB (23)

[DOI] [PubMed] [Google Scholar] 19.Dei Cas M., Ghidoni R

After intake of Pycnogenol , constituents and metabolites have been also detected in blood cells, synovial fluid and saliva indicating a substantial distribution in compartments other than serum