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TDP-43 aggregates similarly compromise mitochondrial function, causing fragmentation and bioenergetic failure as organelles become trapped in the soma rather than distributing to distal motor neurone processes [101]

Consequently, any impairment of liver function, particularly in individuals with chronic liver disease, can lead to substantial alterations in iron regulation [3, 29]

(2019) found iron deposition in the hippocampus of APP/PS1 mice using MRI technology, and histological analysis showed that small glial cells with A deposition in the brain had increased iron overload

Prophylactic treatment of migraine with beta-blockers and riboflavin: differential effects on the intensity dependence of auditory evoked cortical potentials

doi: 10.1097/HEP.0000000000000004

Although clinical findings have revealed that osteoarthritic phenotypes are one of the common complications in patients with hemophilia (Braner, 2018), related pathogenesis and mechanisms of disease progression are yet to be fully understood