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Diabetes - High doses (1000mg or more) of B3 (niacin) can interfere with blood sugar control

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This is especially important for people who are taking ongoing medication and people with internal organ problems, such as kidney disease

For more details, you can dive into the interactive Tableau version of this chart

Reviewed and updated: 22 June 2026 Hydroxocobalamin is the form of vitamin B12 you are most likely to meet at the GP surgery rather than the supplement shelf, because it is the form usually given by injection for a confirmed B12 deficiency

No established scientific evidence shows that B12 supplementation directly causes anxiety