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Exons 3 and 4 are used in all the variants and encode the B, C, A, and D domains, which are named based on their similarity to those in insulin

GH/IGF-1 in Muscle and Bone The significance of the GH/IGF-1 axis in the muscular system was highlighted when it was found that calcineurin (CaN), a calcium-calmodulin-dependent protein phosphatase that activates slow isoform of troponin I and myoglobin genes, was regulated by IGF-1 and that inhibiting CaN blocked IGF-mediated hypertrophy of cultured skeletal muscle cells (205)