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Vitamin B-12 is the source of coenzymes for the respective methylation of homocysteine by 5-methyltetrahydrofolate (5-methylTHF) to form methionine and for the mitochondrial conversion of methylmalonyl-CoA to succinyl-CoA ( Figure 1 )

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Researchers working in sports science or applied physiology must account for this classification when designing any protocols involving human subjects

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