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The competitive IRAP inhibitor 23 (HA08) enhances the numbers of dendritic spines in hippocampal cell cultures and HA08 treatment resulted in an increasing number of stubby and mushroom-like spines, a morphology typically associated with mature spines, which are believed to have strengthened synaptic connectivity

This process was documented to initiate at the distal stump during the early inflammatory phase 26,43,44,45

Sleep Medicine, 72 , 28-36

Clinical Application: Cagrilintide is actively used in clinical trials to further assess its efficacy in treating obesity, overweight conditions, and related metabolic disorders

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31.6% of cagrilintide participants achieved greater than 15% weight loss, compared to just 4.7% on placebo