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Rosen 1 , Enrique F Elli 1 , Caroline C Jadlowiec 4 , Shennen A

Damaged mtDNA can perpetuate a cycle of mitochondrial dysfunction and further ROS production, contributing to chronic inflammation ( In IPF, mitochondrial dysfunction, including reduced mtDNA copy number and impaired oxidative phosphorylation, has been implicated in epithelial cell injury and fibrosis (Qian et al., 2022)

doi:10.1055/s-0036-1584295 Serra-Torres S, Bellot-Arcs C, Montiel-Company J, Marco-Algarra J, Almerich-Silla J

Discovery of molecular therapeutics for glaucoma: challenges, successes, and promising directions

While peripheral WBCs are not the canonical choice to observe potentially pathological differences in DNA methylation, primary and secondary lymphoid tissue is unobtainable from a live animal

The authors noted that alternate-day fasting offered slightly greater short-term benefits, but longer studies are needed to confirm durability