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297,298 Microvascular contributions Microvascular dysfunction plays a significant role in the pathogenesis of DPN

doi: 10.1016/j.ejmech.2018.05.036 145 ZhangWChenGChenZYangXZhangBWangSet al

Notoginseng Radix et Rhizoma (Sanqi) and its compound preparation are commonly prescribed in clinical settings for the treatment of DR [19]

When the effects of antineoplastic drugs are considered, it was demonstrated that the treatment with doxorubicin (DOX), an anticancer drug belonging to the anthracycline class, lowered GSH levels in cancer cells, and that exogenous GSH could increase cytosolic GSH levels, thus highly reducing collateral effects of DOX, such as cardiotoxicity and hepatotoxicity

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