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This doesn't mean they're dangerous, but it means the full risk profile isn't established with the certainty that approved drugs provide

J Am Chem Soc 137:42154222 Wu H, Huang J (2018) Optimization of protein and peptide drugs based on the mechanisms of kidney clearance

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Moreover, the KEGG pathways associated with these core target genes included neutrophil extracellular trap formation, longevity regulating pathway, riboflavin metabolism, AGE-RAGE signaling pathway in diabetic complications, sphingolipid signaling pathway, p53 signaling pathway, HIF-1 signaling pathway (Fig