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What are the molecular consequences

by the European Commission (742039, to T.P.D., and 101002812, to F.G.)

MC1 Receptor (Melanocortin 1 Receptor) Stimulates melanogenesis: Activation of MC1 on skin melanocytes increases cAMP and activates tyrosinase, resulting in enhanced eumelanin (dark pigment) synthesis and visible skin darkening (tanning) 1

Consistent with the importance of the cellular microenvironment, 3D expansion better preserves NP cell differentiation capacity compared to 2D monolayer culture [61]