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doi: 10.22374/jomh.v15i3.156 38 CaiDYYangYPWuJXuSQGuoKMWangHLet al

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Nicotinamide N-methyltransferase (NNMT) is a key enzyme located in the cytosolic milieu that catalyzes the transfer of methyl group from the co-factor S-(5-Adenosyl)-L-methionine (SAM) to substrates such as nicotinamide (NCA), pyridine, and related analogs, such as quinoline, isoquinoline, and the1,2,3,4 tetrahydroisoquinoline.aliphatic amine NNMT directly regulates the detoxification of endogenous and exogenous drugs/xenobiotics by the formation of methylated metabolic products, such as 1-methyl nicotinamide (1-MNA), methylated pyridiniums, and methylated related analogs

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Unpaired two-tailed Students t -tests were used for the comparisons between two groups

In regions where soil is low in selenium, deficiencies can impair GPx1 expression significantly, as this isoform is particularly sensitive to intake levels