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Biochanin A protects against iron overload associated knee osteoarthritis via regulating iron levels and NRF2/System xc-/GPX4 axis

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Intriguingly, the proinflammatory cytokine IL-23 has been identified as a stimulant for CDK7 expression in CD4+ T cells, further amplifying glycolytic activity through activation of the PKB/mTOR/HIF-1 signaling network in a psoriasis-like mouse model induced by imiquimod (IMQ) (19)

Glycyrrhizic acid primarily exerts renal protective effects by upregulating GPX4 and inhibiting ROS production to inhibit high glucose-induced iron cell death in podocytes (145)

After the discovery of diphenylhydantoin as a chemical drug for seizures in 1938, the attention of physicians and researchers shifted from KD to the new anti-epileptic drug