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Mitochondrial dysfunction, a hallmark of AP, contributes to impaired energy metabolism, oxidative stress, and cellular injury, exacerbating disease progression (35)
Experimental studies demonstrate that these stem cell types modulate the hypoxic milieu via secretion of cytokines, remodeling of the immune microenvironment, and promotion of neovascularization
Disclosures: Marijana Vujkovic: Nothing to Disclose, David Kaplan: AstraZeneca Inc: Grant/Research Support, Roche Genentech: Independent Contractor, Exact Sciences: Grant/Research Support, Glycotest: Grant/Research Support, Sirtex: Advisor, Exelixis: Advisor, AstraZeneca: Advisor, Jonas Ghouse: Nothing to Disclose, Michael Levin: Nothing to Disclose, Joseph Brancale: Nothing to Disclose, Adam Lewis: Nothing to Disclose, Olivia Veatch: Nothing to Disclose, Carolin Victoria Schneider: Nothing to Disclose, Bao-Li Chang: Nothing to Disclose, Anurag Verma: Nothing to Disclose, Kirk Wangensteen: Nothing to Disclose, Dipender Gill: Nothing to Disclose, Chigoziri Konkwo: Nothing to Disclose, Tae-Hwi Schwantes-An: Target RWE: Consultant, Kyung Lee: Nothing to Disclose, Abraham Shaked: Nothing to Disclose, Kim Olthoff: Nothing to Disclose, Maarouf Hoteit: HepQuant, LLC: Advisor, Daniel Dochtermann: Nothing to Disclose, Trina Norden-Krichmar: Nothing to Disclose, Craig Teerlink: Nothing to Disclose, Poornima Devineni: Nothing to Disclose, Kara Maxwell: Nothing to Disclose, Saiju Pyarajan: Nothing to Disclose, Daniel Rader: Nothing to Disclose, Yasuhito Tanaka: Nothing to Disclose, Benjamin Voight: Nothing to Disclose, Silvia Vilarinho: Moderna Therapeutics Inc: Grant/Research Support, Albireo: Speaking and teaching, Lisa Bastarache: Nothing to Disclose, Stefan Stender: Nothing to Disclose, Philip Tsao: Nothing to Disclose, Timothy Morgan: Nothing to Disclose, Julie Lynch: Nothing to Disclose, Kyong-Mi Chang: Virion Therapeutics: Data Monitoring Committee member, GSK: Advisor 2632 ABSENCE OF INTESTINAL MUCIN-2 PROMOTES GOBLET CELL-ASSOCIATED ANTIGEN PASSAGES FORMATION TO PREVENT ETHANOL-INDUCED STEATOHEPATITIS IN MICE Maria Fernanda Raya Tonetti 1 Noemi Cabre 1 Marcos Fernandez Fondevila 1 Alvaro Eguileor 1 Bernd Schnabl 2 Cristina Llorente 2 , 1 University of California San Diego, 2 University of California, San Diego Background: Goblet cells secrete mucins, cytokines, and antimicrobial peptides and participate in the education of the immune system through goblet cell-associated antigen passages (GAPs)
In addition, alterations in lipid metabolism may also involve metabolites related to energy metabolism
doi: 10.1007/s10549-019-05445-z 187 WangJSunTOuyangQHanYXuB
