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These direct GHR-mediated metabolic effects are studied separately from the IGF-1-mediated anabolic axis using selective pathway inhibitors and GHR knockout models

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Quercetin and other flavonoids are known to behave as mild prooxidants resulting in the upregulation of protective genes, such antioxidant enzymes, glutathione, and cytoprotective enzyme Heme Oxygenase HO-1 mediated by activation of the Nuclear factor erythroid 2-related factor 2 (NRF2), a transcription factor upregulating antioxidant response, expression of antioxidant enzymes, and cytoprotective proteins (Ma and He 2012)

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The highest point is Palomani Pass, at 17,060 feet above sea level