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doi: 10.3389/fcell.2015.00083 69 WangZ.KlipfellE.BennettB

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Reducing the expression of acetyl-CoA carboxylase 1 (ACC1) increases the global histone acetylation and gene expression by reducing FA synthesis, 283 and low-potency ACC1 inhibitor TOFA resulted in tumor regression in MYC-induced renal tumors, 284 at the same time, ND-646, a nanomolar inhibitor of ACC1, inhibits tumor fatty acid synthesis and tumor growth of lung cancer in vivo

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