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For GSSG competition assay (Extended Data Figure 4l), the 2x reaction buffer consisted of 10LM [ 3 H]GSSG, 5mM GSSG, 150mM KCl, and 50mM HEPES (pH 7.4)

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The main action of SOD is to reduce the damage caused by superoxide, the most common free radical, by converting superoxide into water and hydrogen peroxide

To overcome these issues, combining therapy with other inhibitors targeting molecules in the downstream pathways or immunotherapy is under investigation with great potential for patients with KRAS-driven cancers

VAS, visual analogue scale