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aegypti strain from Singapore, introgressed into the genetic background of the Susceptible Rockefeller strain, helped identified four CYP 450 genes, CYP6BB2 , CYP6Z8 , CYP9M5 , and CYP9M6 [181], that were associated with pyrethroid resistance through enhanced detoxification

250 The second RCT reported in a much larger sample (131 BCG patients, 134 placebo patients) no differences in response rate between treatment arms (21% in the BCG group compared to 12% in the placebo groups) at seven months with 95% of patients in each group reporting at least one AE

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Common interference mechanisms include, but are not limited to, aggregation, redox cycling, metal chelation, and chemical reactivity with assay components or protein nucleophiles