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Finally, ELISA analysis showed that L-carnosine markedly decreased the secretion of the pro-inflammatory cytokines IL-6 and TNF- following LPS stimulation (Figures 6G, H), indicating an anti-inflammatory effect

Ferroptotic cancer cells also release danger-associated lipids and iron intermediates that recruit and activate macrophages, creating positive or negative regulatory loops ( 5 Iron homeostasis and immune regulation in the tumor microenvironment 5.1 Impact of macrophage polarization states on iron metabolism During early tumorigenesis, M1-type tumor-associated macrophages (TAMs) facilitate cellular iron uptake via transferrin receptor 1 (TfR1/CD71), while ferritin (FT) restricts iron efflux, resulting in iron sequestration

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