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Despite compelling preclinical evidence for fibrosis resolution and anti-inflammatory effects, formidable translational barriersincluding the limited persistence (107), and host immune clearance (108) of adoptively transferred macrophagesmust be overcome before the clinical potential of CAR-M can be realistically assessed

It is necessary to further study the specific mechanisms by which these drugs inhibit BACH1 in the future, as well as their potential applications in clinical therapy

The most important studies which demonstrate positive impact with varying doses in vitro are those reported by Baker et al., Oedaet al., and Lopes et al., [68, 69, 70]

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Liver IGF-1deficient (LID) mice and ALS knockout (ALSKO) mice exhibited relatively normal growth and development, despite having 75% and 65% reductions in serum IGF-1 levels, respectively