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While multidose ARC-520 and GalNAc-siRNAs such as imdusiran (AB-729) achieve deep HBsAg suppression, it remains unclear whether this alone can reprogram immunity toward functional cure, particularly given that a substantial fraction of HBsAg derives from integrated HBV DNA, which is not addressed by cccDNA-centered approaches [204, 208,209,210]

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