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Pre-clinical vs Clinical Translation Challenges Concentrations that produce robust in-vitro fibroblast responses may not translate predictably to in-vivo or human contexts

[57] These findings offer a new perspective into developing agents that harness the benefit of RNA-based therapeutics, such as improved safety due to the transient nature of their effect

Hence, the facilitation of glutaminolysis leads to the accumulation of excess ammonia within cells, and a high concentration of ammonia is a potent inducer of autophagy 167 (Fig

However, this study did not directly confirm whether PMSCs migrated to the ovaries