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The results of a study concerning the graded expression of the Keap1 gene in mice demonstrated that a 50% reduction of Keap1 activity does not induce Nrf2 accumulation, whereas a 75% reduction is enough to elicit this effect (Taguchi et al., 2010)

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In addition, we evaluated the proportion of CD8 + T cells producing IFN- within tumor tissues, and a significant increase was observed in this population within the BsNb-ncAA treated group as compared to the other treatment group (Fig