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2003 doi: 10.1096/fj.02-0867fje

Exercise modulates polarization of tams and expression of related immune checkpoints in mice with lung cancer

Les consquences d'une carence en glutathion sont lies l' augmentation du stress oxydatif et peuvent se manifester soit par des troubles du systme immunitaire (maladie) , soit par des dysfonctionnements enzymatiques , entranant terme des dommages aux structures cellulaires, une acclration du processus de vieillissement et une aggravation des maladies existantes

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PMID: 25584005

The AGE-RAGE signaling pathway The formation of AGEs also triggers activation of the receptor for AGEs (RAGE), which in turn exacerbates oxidative stress and inflammation through the stimulation of signaling pathways, such as NFB and NADPH oxidase, thereby sustaining a self-perpetuating cycle of vascular and tissue injury [24]