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Combined with peripheral dopa decarboxylase inhibitors in fixed-dose formulations, it is converted into dopamine after crossing the bloodbrain barrier, effectively compensating for the dopaminergic deficit in the nigrostriatal pathway and significantly improving core motor symptoms such as bradykinesia, rigidity, and tremor [100], long-term use is associated with motor complications including wearing-off phenomena, dyskinesias, and "onoff" fluctuations, as well as peripheral dopaminergic adverse effects such as nausea, vomiting, and hypotension [101, 102]

The likelihood of these symptoms significantly increases from Braak stages I/II to Braak stages III/IV (Ehrenberg et al., 2018)

Peptides are natural tiny molecules in your body

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Kim, H.-N

The human mycobiome in health and disease