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these low levels can prompt anti-doping rule violations even when no physiologically significant exposure occurs

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To avoid confounding bias from the crossover intervention, data from this later phase will not be used for the primary hypothesis testing

, they had to be preceded by the already advanced significant damage in the brain), the seizures lasted for a few hours throughout the progressing brain and liver damage (as seen with worsening throughout the 3-24 h post-paracetamol period)

Polymorphisms in the genes encoding drug transporters and metabolizing enzymes may influence the pharmacokinetics of vancomycin, increasing the risk of nephrotoxicity

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