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This review was written without direct funding

In addition, intracellular scaffold proteins interface with the actin cytoskeleton, linking transmembrane tight junction proteins to the cytoskeleton and subsequently acting as a molecular target for tight junction dysregulation in various pathways, including the Zot and zonulin pathways, which both involve the dysregulation of tight junction proteins to induce alterations in intestinal permeability (7, 1115)

On paper the two are complementary rather than redundant one stops a leak, the other adds water to the tank

This mineral is also urgently needed during pregnancy and for childhood development, sexual maturation, and male fertility

Soares et al., 2023)

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