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GSTs are able to conjugate glutathione (-l-glutamyl-l-cysteinyl-glycine, GSH) to a wide range of hydrophobic and electrophilic molecules including many carcinogens, therapeutic drugs, and many products of oxidative metabolism, making them less toxic and predisposed to further modification for discharge from the cell (Fig

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GSH-responsive nanoprobes provide tumor-targeted imaging by switching on MRI, fluorescence, or photoacoustic contrast in the tumor microenvironment [97]

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These two proteins are critical components of the extracellular matrix and play a role in maintaining the skin tissues' structural integrity