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Revolutionizing personalized medicine: synergy with multi-omics data generation, main hurdles, and future perspectives

For instance, exosome circ-PVT1 has been shown to contribute to cisplatin resistance by regulating autophagy, invasion, and apoptosis via the miR-30a-5p/YAP1 axis in gastric cancer cells (90)

Interestingly, increased nuclear translocation of Nrf2 and upregulation of HO-1 protein expression have been reported to significantly ameliorate TBI-induced behavioral deficits in TBI rats [62]