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The amount of material needed for significant rejuvenation may be cost prohibitive, and results are in most cases not permanent, requiring some level of maintenance therapy

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Throughout the experiment, animals were maintained under anaesthesia, and artificial cerebrospinal fluid (NaH 2 PO 4 2.0 mM, MgCl 2 1.0 mM, CaCl 2 1.2 mM, KCl 2.7 mM and NaCl 145 mM) was constantly pumped through the microdialysis probe at a rate of 0.5 L/min

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Due to its regulatory rather than stimulatory mechanism, Epithalon is considered suitable for long-term longevity support when used in structured cycles

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