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Neuron 5: 841846

Matsumoto, K., Funakoshi, H., Takahashi, H

doi: 10.4103/0019-5154.57602

TMAO activates the NLRP3 inflammasome through three distinct signaling mechanisms: mitochondrial dysfunction induced by Rac1-NOX2-dependent ROS production, which causes cytosolic release of oxidized mtDNA