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Consequently, there is an increased influx of FFAs into the liver, driven both by reduced inhibition of lipolysis and by an increase in de novo synthesis of FFAs [49]

Here, it binds to antioxidant-responsive elements, initiating the transcription of various antioxidant genes [such as NAD(P)H:quinone oxidoreductase 1, glutathione S-transferase, heme oxygenase 1, -glutamylcysteine ligase and GSH] (58)