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155, 2011 Although ascorbate and glutathione pools may be congured to respond to perturbation in a compensa- tory manner (discussed further below), it is now clear from studies of Arabidopsis mutants that the two compounds have specic functions and should not merely be considered as interchangeable antioxidants

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Saturation of GSH uptake also explains the lag period before growth resumption to be longer at 200 M than at 100 M GSH, as GSH remains longer in the medium under the former condition

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Thus, these findings underscore CBS-mediated cysteine metabolism as a pivotal downstream effector in DDX3X-driven lung cancer progression