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Hirsch FR, Varella-Garcia M, Bunn PA, Di Maria MV, Veve R, Bremnes RM, et al

All u SOD1 variants had K D values greater than u SOD1 WT (9 1 nM), implying that these single residue substitutions are sufficient to disturb the quaternary structure (Table 1)

Taken together, these results suggested that redox control pathways in subcellular compartments are separately and precisely controlled to meet the specific redox requirements in these distinct locations.