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The treatment with DHYZ reduced levels of ROS and MDA, thereby suppressing the expression of markers associated to ferroptosis, including Fe 2+ , SLC7A11, and GPX4 ( Naodesheng pills (NDSP) are commonly prescribed traditional Chinese medicines consisting of Panax notoginseng (Burk.) F

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To further investigate one-carbon metabolism disruption, we looked at related pathways that utilize formate intermediates such as the methylation cycle, transsulfuration, and purine biosynthesis