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Endogenous GCLC was detected with anti-GCLC antibody in the HA-P300 pull-down complex (Fig

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on the other hand, combining ferroptosis with biological materials is a promising alternative strategy

doi: 10.1038/s41419-021-03559-1 18 WangJDengBLiuQHuangYChenWLiJet al

Introduction Atopic dermatitis (AD) is one of the most common chronic inflammatory cutaneous diseases with a relapsing-remitting course characterized by pruritus, dry skin, and eczema lesions ( Among all of the inflammatory cytokines, TNF- has gained a lot of attention due to its multiple effects in promoting cells death, including receptor-interacting protein 1 (RIP1)-independent apoptosis, RIP1-dependent apoptosis (RDA), and necroptosis ( As the main bioactive component of tea polyphenols, the health benefits of epigallocatechin-3-gallate (EGCG) have been widely used in treating a wide range of diseases, based on its anti-inflammatory and antioxidant properties ( However, the low bioavailability, instability, and cytotoxicity at a large dose limited the clinical application of EGCG