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The effects of curcumin on weight loss among patients with metabolic syndrome and related disorders: a systematic review and meta-analysis of randomized controlled trials

As a selective substrate site-targeting inhibitor of nicotinamide N-methyltransferase (NNMT) the cytosolic enzyme responsible for the methylation of nicotinamide using S-adenosylmethionine (SAM) as a methyl donor 5-Amino-1MQ is studied as a tool compound for investigating NNMT enzyme activity, NAD salvage pathway interactions, and methylation pathway dynamics in controlled in-vitro experimental systems

Williams et al., 2012)

An NNMT Inhibitor Increases Strength and Alleviates the Need for Muscle Recovery To test the effects of 5-amino-1MQ, the Texas-based research group divided aged mice into four groups: one sedentary group with low activity, another sedentary group given the compound, a group that underwent rigorous exercise without treatment, and another that underwent exercise and treatment

The rationale was that direct delivery to the joint would maximize local efficacy while minimizing systemic exposure

How vitamin B12 (cyanocobalamin) works