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These alterations occur in particular in the central DNA-binding domain (DBD) and are classified as mutations affecting DNA contact, as a result of changes of critical amino acids indispensable for p53 binding, such as R248Q (rs11540652), R273H (rs28934576), and R282W (rs28934574), or conformational mutations that lead to either a loss of protein structure or altered conformation, such as R175H (rs28934578), Y220C (rs121912666), G245S (rs28934575), and R249S (rs28934571) (Zhou et al

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Observed concentrations of levosimendan and its metabolites were significantly lower in neonates/infants than in adults

Levine RL, Garland D, Oliver CN, et al (1990) [49] Determination of carbonyl content in oxidatively modified proteins

The non-enzymatic ACC decomposition to ethylene was observed in the presence of KCN (in vitro assay), similarly, an increase in ethylene emission from apple embryos shortly pretreated with HCN was demonstrated (Gniazdowska et al