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Elevated insulin causes an increase of free serum IGF-1, nevertheless, as resistance to insulin progresses, the liver becomes insensitive to insulin-mediated suppression of IGFBP-1 [254, 256]

Specifically, they found that patients who consumed at least 4 cups of coffee per day had a 52% lower risk of CRC-specific death and a 30% reduced risk of all-cause death

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Hongliang Y, Xudong Y, Xian X, Meiqian X, Yanlei Y, Chunling X et al

USA 112 , 81738180 (2015)

Herbal medicine use and predictors among pregnant women attending antenatal care in Ethiopia: a systematic review and meta-analysis