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Moreover, inflammatory mediators, such as Nucleotide-binding oligomerization domain-like receptor protein 3 (NLRP3) and Tumor necrosis factor-alpha (TNF-) increased, while pivotal proteins involved in dendritic and synaptic development, such as Synaptophysin (SYP), postsynaptic density protein 95 (PSD95) and brain-derived neurotrophic factor (BDNF) decreased in APP/PS1 mice

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Preclinical studies indicate that senescent cell burden is low in young rodents and increases with chronological age in several tissues (33, 34)

Meanwhile, their downstream molecules, such as eIF2 and GADD153/CHOP, were also elevated, ultimately resulted in apoptosis